APPLIED NANOBIOLOGY FOR BONE REPAIR™

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NanoBone is a unique and patented advanced bone grafting material. It incorporates nano-crystalline particles of hydroxyapatite (HA) that are similar in size, chemistry, and morphology to HA particles occurring in human bone. Most synthetic bone graft products use very large particles (1-3 mm) of bioceramic as the basis of their product. Although the body recognizes the chemistry of some of these products, the size is foreign. The body struggles to remodel these large bioceramic particles because they are 100,000 times the size of naturally occurring HA..

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Nanocrystalline Hydroxyapatite (HA)

• Similar size, chemistry, and morphology as HA in human bone

• No bonding between nanocrystals - unsintered

• Autologous proteins adsorb rapidly to surface

Amorphous Silica Gel Matrix (ASG)

• Highly nanoporous with large internal surface area

• Holds HA nanocrystals in place

• Extremely hydrophilic

• Releases SiO2 triggering angiogenesis, the basis for bone formation

• Is rapidly replaced by autologous organic matrix

NanoBone incorporates

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NanoBone incorporates nano-crystalline HA (3 nm x 50 nm) into an amorphous silica gel (ASG). This allows for sequestration of nano sized HA particles at the surgical site while upregulating the bone healing cascade through the influence of silicon

Upon implantation

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Upon implantation of NanoBone, the ASG begins to be replaced with autologous materials including collagenous proteins, mesenchymal stem cells and other growth factors. The matrix change where ASG is replaced by autologous materials occurs within 14 days of implantation.

NanoBone performs

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NanoBone performs as well as the competing gold standards for bone grafting, with lower risks than autograft and at a lower price than BMP or stem cell containing products. It is designed to be used as a standalone graft and does not require the addition of autograft, blood, or bone marrow aspirate. It has been used successfully in Europe for ten years in approaching 400,000 cases.

NanoBone Synthetic Bone Graft is the clinically-proven, cost-effective replacement for all other bone grafting materials.

NanoBone SBX Putty

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In NanoBone SBX Putty, we have a product that combines Applied NanoBiology for bone repair with perfect handling for the surgeon. NanoBone SBX Putty has the same Indications for Use as NanoBone Granules, that is, as a bone void filler for use in the treatment of surgically created osseous defects or defects resulting from traumatic injury to bone.

NanoBone QD

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To extend the usability of NanoBone, we put the perfect handling of NanoBone SBX Putty in an applicator designed for QD – quick delivery. This easy-to-use device facilitates rapid implantation of our advanced bone graft in a controlled and precise manner. Artoss developed NanoBone QD to provide these benefits in a cost-effective delivery system.